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I guess it will boil down to experimentation, as you say. I sent an email to PixelGenius' tech support, asking the same question, and PM'ed Jeff Schewe on this forum. No response from either

Maybe it's not a valid question?? Seems like they'd want to help people get the best out of their products, though.... Or maybe I'm just brain dead...

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Well, I'm happy to report that I just received an email from Bruce Fraser, responding to my query. Thanks, Bruce!
Bruce conjectured that perhaps "0" is just that, no sharpening, and that the negative settings actually involve adding some smoothing to the unsharpened output. I haven't had a chance to experiment to that effect, yet (not with my camera or computer - they're at home).
Either way, though, it will simply boil down to playing with it to see what works best, it seems....
Dave